14 December 2019 |       Share
 
 
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repTOP™ ERE-Luc mouse
repTOP™ PPRE-Luc mouse
repTOP™ mitoIRE mouse
repTOP™ Ubi-Luc2 mouse
repTOP™ Ube2g2-Luc2 mouse

Introducing the repTOP™ Ubi-Luc2 model






The
repTOP Ubi-Luc2 series of mice is conceived by TOPsrl to meet the requests of  systems where the expression of the reporter was ubiquitous and of different intensity: 


-  Low (Lseries)

-  Medium (Mseries)

-  High (Hseries)

 
All the mice of the present series have ubiquitous expression of the Luc2 reporter* as tested by  TOPsrl  with its SATURN proprietary technology.

 

The luminescent reporter Luc2 is expressed in all tissues as shown by ex vivo imaging and by enzymatic luciferase assay (25 organs tested). The expression analysis during time and in different generations confirms a constant expression of Luc2 and a very low inter-individual variability in adult mice.

The homozygous mouse is viable, fertile, normal in size and does not display any gross physical or behavioral abnormalities.

The repTOP Ubi-Luc2M8 is a tool to detect specific biological events when used combined with pro-luciferin (see references), and it could be used as a source of any cell types expressing luciferase reporter.




References