In a recent publication: “LT175 is a novel PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties” appeared in the last issue of J. Biol. Chem. (published online January 22, 2014) authors demonstrate, thanks’ to repTOP PPRE-Luc mouse model, that a new PPAR ligand LT175 modulate lipid and glucose metabolism with reduced adipogenic activity, which may be used as a model for a series of novel molecules with improved pharmacological profile for the treatment of dyslipidemia and type 2 diabetes.
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