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22 01 2014

PPRE-Luc mouse model


In a recent publication: “LT175 is a novel PPARα/γ ligand with potent insulin sensitizing effects and reduced adipogenic properties” appeared in the last issue of J. Biol. Chem. (published online January 22, 2014) authors demonstrate, thanks’ to repTOP PPRE-Luc mouse model, that a new PPAR ligand LT175 modulate lipid and glucose metabolism with reduced adipogenic activity, which may be used as a model for a series of novel molecules with improved pharmacological profile for the treatment of dyslipidemia and type 2 diabetes.
 
23 07 2013

A novel insights on our repTOP ERE-Luc mouse model


In a recent publication: “Estrogen receptor-mediated signalling in female mice is locally activated in response to wounding” appeared in the last issue of Molecular and Cellular Endocrinology (375: 2013 pag. 149–156) authors demonstrate the possibility to apply the repTOP ERE–Luc transgenic mouse model to demonstrate novel temporally regulated periwound activation of estrogen signalling in female mice.
 
17 04 2013

Join TOP srl at the 12th FELASA and 12th SECAL joint congress entitled: ‘Animal Research: Better Science from Fewer Animals’ (10-13 June 2013 Barcelona)


This year at the FELASA meeting, TOP srl will present the poster “A Reporter Mouse to Measure Drug Myelotoxicity in Time”, highlighting a novel application of the repTOP™mitoIRE mouse model.
 
06 03 2013

Join TOP srl at the American Association for Cancer Research (AACR) Annual Meeting 2013 (April 6-10 2013 Washington DC)


This year at the AACR meeting, TOP srl will present the poster “A Reporter Mouse to Measure Drug Myelotoxicity in Time” (#4416), highlighting a novel application of the repTOP™mitoIRE mouse model. The poster is scheduled for presentation in the Session Experimental and Molecular Therapeutics # 31 on Tuesday Apr 9, 2013 1:00 p.m. - 5:00 p.m. Stefano di Giovine, Business Development Director of TOP srl, will be able to meet you to discuss on further applications of TOP srl models for in vivo imaging at the booth of our exclusive distributor for the North America: Charles River Laboratories, Inc. (booth #2034). On Sunday, April 7, at 3.00 p.m. Dr Di Giovine will coordinate a scientific roundtable “Seeing Research in a Better Light: Using the TOP Reporter Mice for Cancer Research” To schedule a meeting with TOPsrl at the AACR Annual Meeting please contact us at top@top-mice.com.
 
15 11 2012

TOP srl announces a collaboration with Charles River Laboratories International Inc. for the marketing and sales in North America (USA and Canada) of its products.


TOP (Transgenic Operative Products) srl announced that it has signed an important agreement to promote and market 3 of its products in North America (U.S. and Canada) with Charles River Laboratories International, Inc. (NYSE: CRL), a world leader provider of models for biological research and pharmaceutical industry.
 

 
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