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PPRE-Luc mouse model
In a recent publication: “LT175 is a novel ...
A novel insights on our repTOP ERE-Luc mouse model
In a recent publication: “Estrogen receptor...
Join TOP srl at the 12th FELASA and 12th SECAL joint congress entitled: ‘Animal Research: Better Science from Fewer Animals’ (10-13 June 2013 Barcelona)
This year at the FELASA meeting, TOP srl will...
Join TOP srl at the American Association for Cancer Research (AACR) Annual Meeting 2013 (April 6-10 2013 Washington DC)
This year at the AACR meeting, TOP srl will p...


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Rando G, Horner D, Biserni A, et al. An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals. Mol Endocrinol. 2010 Apr;24(4):735-44.

Rando G, Biserni A, Ciana P, et al. Profiling of drug action using reporter mice and molecular imaging. Methods Mol Biol. 2010;602:79-92.

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Ottobrini L, Ciana P, Moresco R, et al. Development of a bicistronic vector for multimodality imaging of estrogen receptor activity in a breast cancer model: preliminary application. Eur J Nucl Med Mol Imaging. 2008;35(2):365-78.

Stell A, Belcredito S, Ramachandran B, et al. Multimodality imaging: novel pharmacological applications of reporter systems. Q J Nucl Med Mol Imaging. 2007;51(2):127-38.

Stell A, Biserni A, Della TS, et al. Cancer modeling: modern imaging applications in the generation of novel animal model systems to study cancer progression and therapy. Int J Biochem Cell Biol. 2007;39(7-8):1288-96. 

Penza M, Montani C, Romani A, et al. Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines. Toxicol Sci. 2007;97(2):299-307.

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Maggi A, Ciana P. Reporter mice and drug discovery and development. Nat Rev Drug Discov. 2005;4(3):249-55.

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Ciana P, Di Luccio G, Belcredito S, et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol Endocrinol. 2001;15(7):1104-13.

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