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PPRE-Luc mouse model
In a recent publication: “LT175 is a novel ...
A novel insights on our repTOP ERE-Luc mouse model
In a recent publication: “Estrogen receptor...
Join TOP srl at the 12th FELASA and 12th SECAL joint congress entitled: ‘Animal Research: Better Science from Fewer Animals’ (10-13 June 2013 Barcelona)
This year at the FELASA meeting, TOP srl will...
Join TOP srl at the American Association for Cancer Research (AACR) Annual Meeting 2013 (April 6-10 2013 Washington DC)
This year at the AACR meeting, TOP srl will p...

PUBLICATIONS

Benedusi V, Martorana F, Brambilla L, et al. The peroxisome proliferator-activated receptor γ (PPARγ) controls natural protective mechanisms against lipid peroxidation in amyotrophic lateral sclerosis. J Biol Chem. 2012 Oct 19;287(43). Epub 2012 Aug 21

Rocoroni C, Rizzi N, Brunialti E, et al. Molecular imaging of cytochrome P450 activity in mice. Pharmacol Res. 2012 May;65(5):531-6. Epub 2012 Feb 25.

Goerman F. et al. Molecular imaging of NF-Y transcriptional activity maps proliferation sites in live animals. Molecular Biology of the Cell, 2012  (23) 1467-1474

Ramachandran B, Mäkelä S, Cravedi JP, et al. Estrogen-like effects of diet-derived cadmium differ from those of orally administered CdCl(2) in the ERE-luc estrogen reporter mouse model. Toxicol Lett. 2011 Apr 25; 202(2):75-84.

Della Torre S, Biserni A, Rando G, et al. The conundrum of estrogen receptor oscillatory activity in the search for an appropriate hormone replacement therapy. Endocrinology. 2011 Jun;152(6):2256-65. Epub 2011 Apr 19.

Della Torre S, Rando G, Meda C, et al. Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1.Cell Metab. 2011 Feb 2;13(2):205-14.

Nebbioso A, Dell'Aversana C, Brugge A, et al. HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation.J Mol Endocrinol. 2010 Oct;45(4):219-28.

Dondi D, Piccolella M, Biserni A, et al. Estrogen receptor beta and the progression of prostate cancer: role of 5alpha-androstane-3beta,17beta-diol. Endocr Relat Cancer. 2010 Jul 28;17(3):731-42.

Rando G, Horner D, Biserni A, et al. An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals. Mol Endocrinol. 2010 Apr;24(4):735-44.

Rando G, Biserni A, Ciana P, et al. Profiling of drug action using reporter mice and molecular imaging. Methods Mol Biol. 2010;602:79-92.


Maggi A, Rando G. Reporter mice for the study of intracellular receptor activity. Methods Mol Biol. 2009;590:307-16.

 
Rando G, Arca S, Casiraghi E, et al. Automatic segmentation of mouse images. Stereology and Image Analysis. Ecs10- Proceedings of the 10th European Congress of ISS. The MIRIAM Project Series, ESCULAPIO Pub. Co., Bologna, Italy, 2009.

Montani C, Penza M, Jeremic M, et al. Estrogen receptor-mediated transcriptional activity of genistein in the mouse testis. Ann N Y Acad Sci. 2009; 1163:475-7.

Brufani M, Ceccacci F, Filocamo F, et al. Novel Locally Active Estrogens Accelerate Cutaneous Wound Healing. A Preliminary Study. Mol Pharmaceutics 2009; 6(2): 543–556

Rando G, Ramachandran B, Rebecchi M, et al. Differential effect of pure isoflavones and soymilk on estrogen receptor activity in mice. Toxicol Appl Pharmacol. 2009; 237(3):288-97.

Stell A, Belcredito S, Ciana P, et al. Molecular imaging provides novel insights on estrogen receptor activity in mouse brain. Mol Imaging. 2008; 7(6):283-92.

Montani C, Penza M, Jeremic M, Biasiotto et al. Genistein is an efficient estrogen in the whole-body throughout mouse development. Toxicol Sci. 2008; 103(1):57-67.

Biserni A, Giannessi F, Sciarroni AF, et al. In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886). Mol Pharmacol. 2008;73(5):1434-43.  

Ottobrini L, Ciana P, Moresco R, et al. Development of a bicistronic vector for multimodality imaging of estrogen receptor activity in a breast cancer model: preliminary application. Eur J Nucl Med Mol Imaging. 2008;35(2):365-78.

Stell A, Belcredito S, Ramachandran B, et al. Multimodality imaging: novel pharmacological applications of reporter systems. Q J Nucl Med Mol Imaging. 2007;51(2):127-38.

Stell A, Biserni A, Della TS, et al. Cancer modeling: modern imaging applications in the generation of novel animal model systems to study cancer progression and therapy. Int J Biochem Cell Biol. 2007;39(7-8):1288-96. 

Penza M, Montani C, Romani A, et al. Genistein accumulates in body depots and is mobilized during fasting, reaching estrogenic levels in serum that counter the hormonal actions of estradiol and organochlorines. Toxicol Sci. 2007;97(2):299-307.

Ciana P, Biserni A, Tatangelo L, et al. A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. Mol Endocrinol. 2007;21(2):388-400.

Ciana P, Scarlatti F, Biserni A, et al. The dynamics of estrogen receptor activity. Maturitas. 2006;54(4):315-20.
Ottobrini L, Ciana P, Biserni A, et al. Molecular imaging: a new way to study molecular processes in vivo. Mol Cell Endocrinol. 2006;246(1-2):69-75.

Ottobrini L, Ciana P, Biserni A, et al. Molecular imaging: a new way to study molecular processes in vivo. Mol Cell Endocrinol. 2006;246(1-2):69-75.

Ciana P, Brena A, Sparaciari P, et al. Estrogenic activities in rodent estrogen-free diets. Endocrinology. 2005;146(12):5144-50.

Mussi P, Ciana P, Raviscioni M, et al. Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT. Brain Res Bull. 2005;65(3):241-7.

Maggi A, Ciana P. Reporter mice and drug discovery and development. Nat Rev Drug Discov. 2005;4(3):249-55.

Villa R, Bonetti E, Penza ML, et al. Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice. Toxicol Appl Pharmacol. 2004;201(2):137-48.

Penza M, Bonetti E, Villa R, et al. Whole body action of xenoestrogens with different chemical structures in estrogen reporter male mice. Toxicology. 2004;205(1-2):65-73.

Maggi A, Ottobrini L, Biserni A, et al. Techniques: reporter mice - a new way to look at drug action. Trends Pharmacol Sci. 2004;25(6):337-42.

Ciana P, Raviscioni M, Mussi P, et al. In vivo imaging of transcriptionally active estrogen receptors. Nat Med. 2003;9(1):82-6.

Di Lorenzo D, Villa R, Biasiotto G, et al. Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice. Endocrinology. 2002;143(12):4544-51.

Ciana P, Di Luccio G, Belcredito S, et al. Engineering of a mouse for the in vivo profiling of estrogen receptor activity. Mol Endocrinol. 2001;15(7):1104-13.

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