24 August 2017 |       Share
 
 
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CASE STUDIES
Myelotoxicity
Skin Wound Healing
Skin Toxicity Study
Endocrine Disruptors
Hepato-Toxicology
Lipid Metabolism
Carcinogenicity
Neuroinflammation
Lung Inflammation
Oxidative Stress in NDs
Estrogenic Drugs Profile

repTOP Systems are the Revolutionary Approach Versus Conventional Procedures for Preclinical Studies


"In this section we report case studies in which we show the application of our reporter mice models that are much more rapid and predictive than classical methods, thanks to the use of in vivo optical imaging"




repTOP mice strengthen the role of molecular imaging in drug development, thus enabling to follow molecular pathways in living organisms in space and time. Reporter mice and in vivo optical imaging are the new way to dramatically change the approach to the study of pharmacodynamics and pharmacokinetics.

The major advantages of TOP srl assay versus conventional procedures are:
- a significant reduction of research time
- a significant cutback in costs
- the direct, in vivo quantification of the dose effect
- a detailed temporal analysis of the extant of pharmacological and toxicological effects
- the full compliance of the 3R regulations with a significant reduction of the number of animals to be used and their distress

The features that make TOP reporters ideals are:
- low background-highsignal/noise ratio
- unexprensive, easy to detect readout
- reproducibility
- direct and quantitative correlation between stimulus and signal intensity
- ubiquitous, regulated expression


 
Just have a look to the case studies to better understand the power of our models!