repTOP™ mouse models allow a direct visualisation of drug action in vivo, leading to a new perspective in drug discovery in which pharmacokinetics and pharmacodynamics are combined. Thanks to the SATURN validation, readouts are stable across different tissues and organs, different ages and sexes. This means that the system is suitable for the detection of even subtle differences in drug action between the sexes, to study activity in elderly animals and to monitor effects during pregnancy and foetal life. Furthermore, crossing repTOP™ mice with human disease mouse models, including age-related degenerative diseases, allows direct detection of the efficacy of pharmacological compounds in such conditions.
Here we introduce you to the models we have already on the market:
· for estrogen receptors (Endocrinology, Women Health), the repTOP™ ERE-Luc mouse
· for PPARs (Metabolic and Cardiovascular Diseases), the repTOP™ PPRE-Luc mouse
· for a source of any cell types expressing luciferase reporter and to detect specific biological events
when used combined with pro-luciferin, therepTOP™ Ubi-Luc2 mouse
TOP srl is now launching the new model for measuring cell proliferation in vivo.
Discover the repTOP™ mitoIRE mouse useful for reasearch in oncology, immunology and regenerative medicine.
In addition, TOP srl is developing new in-house-generated projects, but is eager to apply its experience and technology for the development of custom models.