11 December 2017 |       Share
 
 
ABOUT US
Nice to meet you!
   
TECHNOLOGY
Our edge for you
   
PRODUCTS
The main products
   
SERVICES
We can help you!
   
CASE STUDIES
Model Applications
   
WEBINAR
Let's see how!
   
CONTACT
Get in touch!
 
PRODUCTS
repTOP™ ERE-Luc mouse
repTOP™ PPRE-Luc mouse
repTOP™ mitoIRE mouse
repTOP™ Ubi-Luc2 mouse
repTOP™ Ube2g2-Luc2 mouse

NEWS

PPRE-Luc mouse model
In a recent publication: “LT175 is a novel ...
A novel insights on our repTOP ERE-Luc mouse model
In a recent publication: “Estrogen receptor...
Join TOP srl at the 12th FELASA and 12th SECAL joint congress entitled: ‘Animal Research: Better Science from Fewer Animals’ (10-13 June 2013 Barcelona)
This year at the FELASA meeting, TOP srl will...
Join TOP srl at the American Association for Cancer Research (AACR) Annual Meeting 2013 (April 6-10 2013 Washington DC)
This year at the AACR meeting, TOP srl will p...

'READY TO GO' MOUSE MODELS

repTOP™ mouse models allow a direct visualisation of drug action in vivo, leading to a new perspective in drug discovery in which pharmacokinetics and pharmacodynamics are combined. Thanks to the SATURN validation, readouts are stable across different tissues and organs, different ages and sexes. This means that the system is suitable for the detection of even subtle differences in drug action between the sexes, to study activity in elderly animals and to monitor effects during pregnancy and foetal life. Furthermore, crossing repTOP™ mice with human disease mouse models, including age-related degenerative diseases, allows direct detection of the efficacy of pharmacological compounds in such conditions.

Here we introduce you to the models we have already on the market:


·       for  estrogen receptors (Endocrinology, Women Health), the repTOP™ ERE-Luc mouse

·       for PPARs (Metabolic and Cardiovascular Diseases), the repTOP™ PPRE-Luc mouse

·       for a source of any cell types expressing luciferase reporter and to detect specific biological events
        when used combined with pro-luciferin, therepTOP™ Ubi-Luc2 mouse

 

NEW!

TOP srl is now launching the new model for measuring cell proliferation in vivo.
Discover the repTOP™ mitoIRE mouse useful for reasearch in oncology, immunology and regenerative medicine.

In addition, TOP srl is developing new in-house-generated projects, but is eager to apply its experience and technology for the development of custom models.




SEEING RESEARCH IN A BETTER LIGHT

repTOP™ mouse models allow a direct visualization of drug action in vivo.