29 August 2016 |       Share
 
 
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TOP and Drug Discovery
Advantages with Reporter Mice
TOP and Toxicology
Drug safety and environmental tox
TOP and Nutraceuticals
Unleashing potentials of food for wellness
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TOP srl integrates imaging techniques into the drug discovery process, with the generation of transgenic animals for measuring drug effects on target.

 

Reporter mice, producing in vivo a biomarker easily detected with imaging techniques, are going to revolutionize the way biological processes can be studied.

Signals are quantitative and are generated with a fast kinetics, enabling the visualization of molecular events in real time, in all the organs, with high precision.

These tools find application in:

Drug discovery and development
Toxicology
Nutraceuticals and functional food.

The use of reporter models increases ethical standards of animal research, because the used techniques are non invasive, and this means a reduction of both the stress caused to the mice and of the number of animals required for gathering the necessary information.

 

repTOP™ mice now available in North America (U.S.A. and Canada) at Charles River GEMs:

repTOP™mitoIRE:       bioindicator of cell proliferation

repTOP™ERE-Luc:      bioindicator of Estrogen Receptors activity

repTOP™PPRE-Luc:   bioindicator of PPARs activity

 

 

NEWS

PPRE-Luc mouse model
In a recent publication: “LT175 is a novel ...
A novel insights on our repTOP ERE-Luc mouse model
In a recent publication: “Estrogen receptor...
Join TOP srl at the 12th FELASA and 12th SECAL joint congress entitled: ‘Animal Research: Better Science from Fewer Animals’ (10-13 June 2013 Barcelona)
This year at the FELASA meeting, TOP srl will...
Join TOP srl at the American Association for Cancer Research (AACR) Annual Meeting 2013 (April 6-10 2013 Washington DC)
This year at the AACR meeting, TOP srl will p...